Investment adviser · CRD 118608

ORBIMED ADVISORS LLC

Investment adviser filing (IA)

NEW YORK, NY, United States · Form ADV filed Aug 18, 2026

Regulatory AUM: $20.6B
Client accounts: 32
Employees: 118
Advisory professionals: 86

Who they report serving

Form ADV · Item 5.D

Client types and their share of reported regulatory assets.

Client type	Clients	Regulatory assets	Share of AUM
Pooled investment vehicles	32	$20,607,970,000	100.0%

Filing source

Form ADV 2126532 · Aug 18, 2026 · Item 5.D

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

Private funds & service providers

33 Private funds

The count excludes feeder funds. Funds in the latest filing appear first, ordered by reported gross assets. Earlier funds retain their last reported values.

ORBIMED ASIA PARTNERS, L.P.Other Private Fund · Last reported Aug 18, 2026$54.9MGross asset value

Form D fundraising filings

CADUCEUS ASIA PARTNERS LP

Fund administrator SS&C TECHNOLOGIES, INC. NEW YORK, New York, United States Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG LLP NEW YORK, New York, United States

Custodian ICICI BANK LIMITED MUMBAI, India Related to adviser: No

Custodian JPMORGAN CHASE BANK, N.A. NEW YORK, New York, United States Related to adviser: No

Custodian SILICON VALLEY BANK NEWTON, Massachusetts, United States Related to adviser: No

Provider details

Annual audit: Yes
Prime brokers: No
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG LLP
PCAOB 185

JPMORGAN CHASE BANK, N.A.
LEI 7H6GLXDRUGQFU57RNE9

Fund details & source

Fund ID: 805-2828173600
Reported beneficial owners: 145
Minimum commitment: $10M
Form D file number: 021-120021

Form ADV 2126532 · Aug 18, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ORBIMED ISRAEL PARTNERS LIMITED PARTNERSHIPOther Private Fund · Last reported Aug 18, 2026$35.8MGross asset value

Form D fundraising filings

OrbiMed Israel Partners Limited Partnership

Fund administrator SS&C TECHNOLOGIES, INC. NEW YORK, New York, United States Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor BRIGHTMAN ALMAGOR ZOHAR & CO. TEL AVIV, Israel

Custodian BANK OF LEUMI LE-ISRAEL B.M. HAIFA, Israel Related to adviser: No

Custodian JPMORGAN CHASE BANK, N.A. NEW YORK, New York, United States Related to adviser: No

Custodian SILICON VALLEY BANK NEWTON, Massachusetts, United States Related to adviser: No

Provider details

Annual audit: Yes
Prime brokers: No
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

BRIGHTMAN ALMAGOR ZOHAR & CO.
PCAOB 1197

JPMORGAN CHASE BANK, N.A.
LEI 7H6GLXDRUGQFU57RNE9

Fund details & source

Fund ID: 805-3239961594
Reported beneficial owners: 76
Minimum commitment: $5M
Form D file number: 021-158558

Form ADV 2126532 · Aug 18, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ORBIMED NEW HORIZONS MASTER FUND, L.P.Hedge Fund · Last reported Aug 18, 2026$13.6MGross asset value

Feeder funds

Fund administrator HEDGESERV (CAYMAN ) LTD. GEORGE TOWN, Cayman Islands Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG LLP NEW YORK, New York, United States

Custodian J.P. MORGAN SECURITIES LLC NEW YORK, New York, United States Related to adviser: No

Custodian THE NORTHERN TRUST INTERNATIONAL BANKING CORPORATION JERSEY CITY, New Jersey, United States Related to adviser: No

Prime broker J.P. MORGAN SECURITIES LLC NEW YORK, New York, United States

Provider details

Annual audit: Yes
Prime brokers: Yes
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG LLP
PCAOB 185

J.P. MORGAN SECURITIES LLC
SEC 8-35008

J.P. MORGAN SECURITIES LLC
CRD 79 · SEC 8-35008

Fund details & source

Fund ID: 805-3072417294
Reported beneficial owners: 85
Minimum commitment: $1M
Form D file number: 021-364898
Form D file number: 021-364899

Form ADV 2126532 · Aug 18, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ROYALTY OPPORTUNITIES S.AR.L.Hedge Fund · Last reported Aug 18, 2026$86KGross asset value

Form D fundraising filings

Royalty Opportunities S.ar.l

Feeder funds

ROYALTY OPPORTUNITIES FEEDER S.A.

Fund administrator SS&C TECHNOLOGIES, INC. NEW YORK, New York, United States Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG LLP NEW YORK, New York, United States

Custodian SILICON VALLEY BANK NEWTON, Massachusetts, United States Related to adviser: No

Provider details

Annual audit: Yes
Prime brokers: No
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG LLP
PCAOB 185

Fund details & source

Fund ID: 805-5067248210
Reported beneficial owners: 195
Minimum commitment: $10M
Form D file number: 021-159807
Form D file number: 021-159808

Form ADV 2126532 · Aug 18, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ORBIMED GLOBAL HEALTHCARE MASTER FUND, L.P.Hedge Fund · Last reported Feb 28, 2023$542MGross asset value

Feeder funds

Fund administrator HEDGESERV (CAYMAN ) LTD. GEORGE TOWN, Cayman Islands Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG (CAYMAN ISLANDS) GEORGE TOWN, Cayman Islands

Auditor KPMG LLP NEW YORK, New York, United States

Custodian CITIBANK (CHINA) CO., LTD. SHANGHAI, China Related to adviser: No

Custodian GOLDMAN SACHS & CO. LLC NEW YORK, New York, United States Related to adviser: No

Custodian GOLDMAN SACHS INTERNATIONAL LONDON, United Kingdom Related to adviser: No

Custodian J.P. MORGAN CLEARING CORP. BROOKLYN, New York, United States Related to adviser: No

Custodian THE NORTHERN TRUST INTERNATIONAL BANKING CORPORATION JERSEY CITY, New Jersey, United States Related to adviser: No

Custodian U.S. BANK NEW YORK, New York, United States Related to adviser: No

Prime broker GOLDMAN SACHS & CO. LLC NEW YORK, New York, United States

Prime broker J.P. MORGAN CLEARING CORP. BROOKLYN, New York, United States

Provider details

Annual audit: Yes
Prime brokers: Yes
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG (CAYMAN ISLANDS)
PCAOB 1323

KPMG LLP
PCAOB 185

GOLDMAN SACHS & CO. LLC
SEC 8-129

J.P. MORGAN CLEARING CORP.
SEC 8-43724

GOLDMAN SACHS & CO. LLC
CRD 361 · SEC 8-129

J.P. MORGAN CLEARING CORP.
CRD 28432 · SEC 8-43724

Fund details & source

Fund ID: 805-7442600650
Reported beneficial owners: 18
Minimum commitment: $25M
Form D file number: 021-204519
Form D file number: 021-212193
Form D file number: 021-220964

Form ADV 1720806 · Feb 28, 2023 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ORBIMED ROYALTY OPPORTUNITIES II, LPHedge Fund · Last reported Feb 25, 2026$168MGross asset value

Form D fundraising filings

OrbiMed Royalty Opportunities II, LP

Fund administrator SS&C TECHNOLOGIES, INC. NEW YORK, New York, United States Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG LLP NEW YORK, New York, United States

Custodian JPMORGAN CHASE BANK, N.A. NEW YORK, New York, United States Related to adviser: No

Custodian SILICON VALLEY BANK NEWTON, Massachusetts, United States Related to adviser: No

Provider details

Annual audit: Yes
Prime brokers: No
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG LLP
PCAOB 185

JPMORGAN CHASE BANK, N.A.
LEI 7H6GLXDRUGQFU57RNE9

Fund details & source

Fund ID: 805-1819901255
Reported beneficial owners: 272
Minimum commitment: $750K
Form D file number: 021-233267

Form ADV 2049754 · Feb 25, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

ORBIMED PRIVATE INVESTMENTS IV, LPOther Private Fund · Last reported Feb 25, 2026$78.8MGross asset value

Form D fundraising filings

Caduceus Private Investments IV, LP

Fund administrator SS&C TECHNOLOGIES, INC. NEW YORK, New York, United States Investor statements: Yes (provided to all investors) Related to adviser: No

Auditor KPMG LLP NEW YORK, New York, United States

Custodian JPMORGAN CHASE BANK, N.A. NEW YORK, New York, United States Related to adviser: No

Custodian SILICON VALLEY BANK NEWTON, Massachusetts, United States Related to adviser: No

Provider details

Annual audit: Yes
Prime brokers: No
Custodians: Yes
Administrator other than the adviser: Yes
External marketing: No

KPMG LLP
PCAOB 185

Fund details & source

Fund ID: 805-2516138908
Reported beneficial owners: 158
Minimum commitment: $10M
Form D file number: 021-137285

Form ADV 2049754 · Feb 25, 2026 · Schedule D 7.B.(1)

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.

Services & filing details

Most recent filing: Aug 18, 2026. View historical filings

Reported services

Pooled investment vehicle management

Compensation

Percentage of assets · Performance-based

Principal office

601 LEXINGTON AVENUE, 54TH FLOOR
NEW YORK, NY, 10022, United States

CRD 118608

Filing source

Form ADV 2126532 · Aug 18, 2026 · Items 1 & 5

Official IAPD profile (latest public filing). Values are the most recently reported in our imported data; the public profile may show a newer filing.